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CAST
is a multivalent all-natural vegetarian formula
acting as a chemosensitizer and an inhibitor
of metastasis as well. CAST ingredients were
judiciously selected for their synergistic
action in order to achieve optimal support
for chemotherapy. Inclusion of Atrium Organo-Mineral
Complex (AOMC) proprietary ingredient makes
CAST a unique formula. Moreover, the various
levels of solubility of CAST ingredients make
it possible to saturate simultaneously both
aqueous and lipidic pools of the human body.
CAST
chemosensitizing activity
The
main strength of CAST resides in its ability
to inhibit P-gp pumps activity in cells. An
in vitro study showed that the drug binding
properties of P-gp toward the representative
chemotherapeutic agent iodoarylazidoprazosin
(IAAP) were inhibited by 86% in the presence
of CAST, as detected by a photoaffinity technique.
The study was done on ovarian hamster cancer
cells expressing high levels of P-gp. Since
drug binding to P-gp is mandatory for drug
extrusion through the pump, inhibition of
IAAP binding on P-gp reflects the inhibition
of P-gp pumping activity. Moreover, it was
shown that CAST action on these cells led
to intracellular accumulation of IAAP.
Based
on these results, CAST is expected to act
as a valuable therapeutic support. By inhibiting
P-gp pumps activity, CAST will allow chemotherapeutic
agents to accumulate within the cancer cells
to better exercise their anti-tumor action
(Fig. 3). In fact, not only should
CAST preserve the sensitivity of the cancer
cells towards chemotherapeutic agents, such
as vincristine, doxorubicin, vinblastine and
etoposide (among others) but it is expected
to even restore it where lost, such as in
chemotherapy refractory tumors.
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