Psoriasis is a chronic skin disease occurring in approximately 3% of the population worldwide. It is characterized by excessive growth of the epidermal keratinocytes, inflammatory cell accumulation and excessive dermal angiogenesis (Nickoloff 1991). Histologic studies, including electron microscopy, have clearly established that alterations in the blood vessel formation of the skin are a prominent feature of psoriasis.

Figure above: Immune mediated events translate into production of pro-angiogenic factors. Uncontrolled angiogenesis, epidermal cell proliferation and localized chronic inflammation result in the formation of a psoriatic plaque.

The use of agents that target vascular changes represents a novel therapeutic strategy in the treatment of inflammatory diseases. Since cartilage is an avascular tissue, it has been hypothesized that there may be factors found in cartilage that inhibit blood vessel formation.

Oral Administration of LCE for Psoriasis: Clinical Trials

Benefits of Topical Use