|ANGIOGENESIS AND PSORIASIS
Psoriasis is a chronic skin disease occurring in approximately 3% of
the population worldwide. It is characterized by excessive growth of the epidermal
keratinocytes, inflammatory cell accumulation and excessive dermal angiogenesis (Nickoloff
1991). Histologic studies, including electron microscopy, have clearly established that
alterations in the blood vessel formation of the skin are a prominent feature of
Figure above: Immune
mediated events translate into production of pro-angiogenic factors. Uncontrolled
angiogenesis, epidermal cell proliferation and localized chronic inflammation result in
the formation of a psoriatic plaque.
The use of agents that target vascular
changes represents a novel therapeutic strategy in the treatment of inflammatory diseases.
Since cartilage is an avascular tissue, it has been hypothesized that there may be factors
found in cartilage that inhibit blood vessel formation.
of LCE for Psoriasis: Clinical Trials
Benefits of Topical